Synthesis of New Benzothiazole Derivatives as Potential Antimicrobial Agents

Abstract

Abstract: During the initial efforts to develop novel antibiotics, a new class of benzothiazoles (3a–n) were designed and synthesized as potential antibacterial and antimycobacterial agents. Most of the synthesized compounds showed good antibacterial activity against the Gram-positive bacteria tested. The compounds 3i exhibited excellent in vitro activity, with a MIC value of 1 µg/mL against Mycobacterium tuberculosis H37Rv. These compounds were also found to have activity against Candida albicans, with a MIC value of 4 µg/mL.

Index Terms: Benzothiazole, fused heterocycles, hydrazones, antibacterial, antimycobacterial