Synthesis of 1, 8-Naphthyridine Derivatives using Biodegradable Starch Sulfuric Acid as Heterogeneous Catalyst

Abstract

2-amino-3-cyano substituted 1,8-naphthyridines has been developed in the presence of starch sulfuric acid (SSA catalyst using aminopyridine, malononitrile, and aromatic aldehydes via Knoevenagel condensation and Michael addition followed by intramolecular cyclization. The SSA catalyst could selectively be converted amino pyridine into 1,8-naphthyridines with good yield in a short period of time at room temperature. This catalyst can be efficiently reused several times without loss of its sustainable activity.

Index Terms: Starch sulfuric acid, naphthyridines, biodegradable solid catalyst, heterogeneous acid catalyst