Synthesis and Anticancer Molecular Docking Studies of Phenothiazine Derivatives

Abstract

Phenothiazine incorporated pyran derivatives are prepared by using N-alkyl-phenothiazine-3-carbaldehydes under ultrasonic/reflux condition by one step synthesis. Improvement in yield is observed when the reaction is carried out under ultrasonic condition compared to classical synthetic method. The synthesized compounds are characterized by using FT-IR, ¹H NMR, ¹³C NMR and mass spectral data. Anticancer docking studies are carried out for the synthesized compounds and different cancer target proteins namely lung cancer, colon cancer, breast cancer and pancreatic cancer and the results are reported.