Solvent and bio-degradable catalyst for the construction of fully-substituted benzenes

Abstract

An economical and efficient green chemical method is developed for the synthesis of multi-functionalized benzene derivatives through a natural biopolymer Cellulose Sulfuric Acid (CSA) as a heterogeneous catalytic sequence of Knoevenagal/Michael/Cyclization under solvent-free conditions at 70oC. The metal-free catalytic system under solvent-free condition processes the reactions with a good efficiency. This protocol should be amenable advantages such as simple workup and recoverability of the biopolymer catalyst and reusing several times without significant decrease in catalytic activity.